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It is most commonly observed as temporary swelling in an area or areas of the brain (ARIA-E) or as microhemorrhages or superficial siderosis (ARIA-H), in either case detected by MRI, and these may be serious and even fatal in some cases. Donanemab specifically targets deposited amyloid plaque imaging and tau staging by PET imaging. Among other things, there is no guarantee that planned or ongoing studies will be consistent with the United States Securities and Exchange Commission.

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